Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MRPL53 (Q96EL3) - Overview - Molecular Target Synopsis

Protein


MRPL53, 39S ribosomal protein L53, mitochondrial
UniProt Q96EL3

Also Known as RM53_HUMAN, MRPL53

Component of the mitochondrial large ribosomal subunit (mt-LSU) (PubMed:28892042, PubMed:25838379, PubMed:25278503). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL53 is located at the L7/L12 stalk.

5OOL
STRUCTURE OF A NATIVE ASSEMBLY INTERMEDIATE OF THE HUMAN MITOCHONDRIAL RIBOSOME WITH UNFOLDED INTERFACIAL RRNA
RCSB/PDB
Inspect Structure
See all 3D Structures for MRPL53

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
112ENSG00000204822ENST00000258105ENSP00000258105Q96EL3-1
70ENSG00000204822ENST00000409710ENSP00000386920

Sub-cellular localization


UniProt: MRPL53 is active in the following subcellular-locations: mitochondrion.
GO terms: MRPL53 is active in the following subcellular-locations: mitochondrial inner membrane, mitochondrial large ribosomal subunit, mitochondrion.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MRPL53 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: EKVX, SN12C, NCI_H322M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SNU-398, NCI-H522, TK

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, NHLF

(see details)

3D Structures


For MRPL53 there are:
3 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis