Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GNPNAT1 (Q96EK6) - Overview - Molecular Target Synopsis

Protein


GNPNAT1, Glucosamine 6-phosphate N-acetyltransferase
Enzyme Classification 2.3.1.4
UniProt Q96EK6

Also Known as GNA1_HUMAN, GNPNAT1, GNA1

Homodimer.

3CXS
CRYSTAL STRUCTURE OF HUMAN GNA1
RCSB/PDB
Inspect Structure
See all 3D Structures for GNPNAT1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GNPNAT1 is active in the following subcellular-locations: endosome membrane, golgi apparatus membrane.
GO terms: GNPNAT1 is active in the following subcellular-locations: cytosol, endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, endosome membrane, Golgi apparatus, Golgi membrane, late endosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GNPNAT1 has gain in 5 cell-lines, loss in 0 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, PC_3, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1915, MFM-223, SNU-398

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HeLa-S3, HSMM

(see details)

3D Structures


For GNPNAT1 there are:
5 structures (7 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis