Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
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Ligand Efficiency Plot
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SIRT1 (Q96EB6) - Domains And Structures - Molecular Target Synopsis

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Structural Sequence Similarity Matches
Domains Covered Gene Name (Uniprot) Solved in Complex with Organism PDB Chain Identity E-Value Resolution Ligands Release Date
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 3ZGO_B 42.15 8.0E-55 1.63Å PGE 2013-03-20
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4Y6Q_C 41.37 2.0E-56 1.9Å OMR 2016-01-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BVH_A 40.3 2.0E-51 1.9Å OAD OCZ 2013-07-17
Sir2 family (100%) (view alignment) cobB (Q9WYW0) - 3D4B_A 37.74 2.0E-32 1.8Å DZD 2008-09-30
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5YQM_A 45.06 3.0E-55 1.735Å A2X 2018-10-17
Sir2 family (100%) (view alignment) HST2 (P53686) - BAKER'S YEAST 1Q17_B 40.26 1.0E-40 2.7Å APR 2003-11-18
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 4IG9_C 100 0 2.64Å - 2013-11-06
Sir2 family (100%) (view alignment) SIR2 (P06700) - BAKER'S YEAST 2HJH_B 40.96 6.0E-58 1.85Å XYQ NCA 2008-04-08
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4Y6Q_D 41.37 2.0E-56 1.9Å OMR 2016-01-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 3GLT_A 40.3 2.0E-51 2.1Å - 2009-06-16
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_C 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 3ZGV_A 42.53 6.0E-56 2.27Å AR6 2013-03-13
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 3GLS_F 40.3 2.0E-51 2.7Å PGE 2009-06-16
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 4I5I_A 100 0 2.5Å 4I5 NAD 2013-01-23
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 4IF6_A 100 0 2.25Å APR 2013-10-23
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN4_A 40.3 2.0E-51 1.3Å OP2 AR6 2013-06-26
Sir2 family (100%) (view alignment) HST2 (P53686) HHF1,HHF2 (P02309) BAKER'S YEAST 1SZD_A 40.26 1.0E-40 1.5Å APR 2004-06-15
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4L3O_B 43.98 4.0E-55 2.518Å MES 2014-02-19
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 3GLR_A 40.3 2.0E-51 1.8Å - 2009-06-16
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5DY4_A 45.06 4.0E-55 1.77Å 5GN NAD 2016-01-13
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 6ISO_G 40.3 2.0E-51 2.95Å - 2019-01-23
Sir2 family (100%) (view alignment) (Q8I6E4) TP53 (P04637) 5OL0_B 42.08 7.0E-48 1.99Å - 2018-02-28
Sir2 family (100%) (view alignment) cobB (Q9WYW0) - 2H2I_A 37.74 2.0E-32 1.8Å ZPG 2006-12-05
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 5D7N_F 40.3 2.0E-51 1.83Å - 2015-12-02
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 2H4F_A 37.74 2.0E-32 2Å NAD 2006-09-05
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 5YTK_F 40.3 2.0E-51 2.7Å - 2017-12-27
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 6ISO_K 40.3 2.0E-51 2.95Å - 2019-01-23
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 2H59_A 37.26 3.0E-31 1.9Å APR 2006-09-05
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 4BV2_B 37.74 2.0E-32 3.3Å OAD OCZ 2013-07-17
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5D7O_A 43.32 2.0E-55 1.63Å AR6 2015-12-02
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4 (P62805) HUMAN 5ZGC_A 40.3 2.0E-51 2.9Å - 2019-04-03
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) RAN (P62826) HUMAN 5FYQ_A 42.53 3.0E-56 3Å - 2016-05-25
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5Y0Z_B 41.37 2.0E-56 1.99Å 8K9 2018-07-25
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 5YTK_D 40.3 2.0E-51 2.7Å - 2017-12-27
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5MAR_A 45.06 4.0E-55 1.89Å AR6 7KE 2017-03-15
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 6ISO_E 40.3 2.0E-51 2.95Å - 2019-01-23
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 3PDH_A 37.74 2.0E-32 1.8Å - 2011-01-19
Sir2 family (100%) (view alignment) SIR2 (P06700) SIR4 (P11978) 4IAO_B 40.96 2.0E-58 2.9Å APR 2012-12-26
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4X3O_A 43.8 3.0E-55 1.5Å - 2016-01-13
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 5BTR_C 100 0 3.2Å STL 2015-07-08
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 5BTR_A 100 0 3.2Å STL 2015-07-08
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 1J8F_A 42.53 8.0E-56 1.7Å - 2001-07-06
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4RMG_A 45.06 4.0E-55 1.88Å 3TE NAD 2015-02-25
Sir2 family (100%) (view alignment) HST2 (P53686) - BAKER'S YEAST 1Q17_A 40.26 1.0E-40 2.7Å APR 2003-11-18
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_D 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5YQO_A 45.06 3.0E-55 1.48Å L5C 2018-10-17
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5MAT_A 45.06 4.0E-55 2.07Å 7KJ 2017-02-08
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4O8Z_A 40.3 2.0E-51 2Å BBI 2015-04-22
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4L3O_D 43.98 4.0E-55 2.518Å MES 2014-02-19
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4RMJ_A 45.06 4.0E-55 1.87Å AR6 NCA 2015-02-25
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5YQL_A 45.06 3.0E-55 1.6Å A2I 2018-10-17
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) TNF (P01375) HUMAN 4Y6O_B 41.37 2.0E-56 1.6Å - 2016-01-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_J 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5G4C_A 42.53 8.0E-56 2Å CNA 2017-05-03
(view alignment) SIRT1 (Q96EB6) - HUMAN 4IF6_B 100 0 2.25Å - 2013-10-23
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) H3F3C (Q6NXT2) HUMAN 5BWO_A 40.3 1.0E-51 2.37Å - 2016-07-13
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4 (P62805) HUMAN 5ZGC_B 40.3 2.0E-51 2.9Å - 2019-04-03
(view alignment) SIRT1 (Q96EB6) - HUMAN 4IG9_F 100 0 2.64Å - 2013-11-06
Sir2 family (100%) (view alignment) cobB (Q9WYW0) - 3JR3_A 37.26 3.0E-31 1.5Å - 2009-09-29
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4HD8_A 40.3 2.0E-51 2.3Å PIT 2012-12-05
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 1J8F_B 42.53 8.0E-56 1.7Å - 2001-07-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_I 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 5YTK_A 40.3 2.0E-51 2.7Å - 2017-12-27
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) (V9H1G0) HUMAN 5Z94_B 40.3 2.0E-51 1.9Å - 2019-02-06
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) HIST1H3A,HIST1H3B,HIST1H3C,HIST1H3D,HIST1H3E,HIST1H3F,HIST1H3G,HIST1H3H,HIST1H3I,HIST1H3J (P68431) HUMAN 4Y6L_A 41.37 2.0E-56 1.6Å - 2016-01-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BVH_B 40.3 2.0E-51 1.9Å AR6 OCZ 2013-07-17
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 4BUZ_A 37.74 2.0E-32 1.9Å OAD OCZ NAD 2013-07-17
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 2H59_B 37.26 3.0E-31 1.9Å 3OD 2006-09-05
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 6ISO_A 40.3 2.0E-51 2.95Å - 2019-01-23
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 3GLS_D 40.3 2.0E-51 2.7Å - 2009-06-16
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 4IG9_A 100 0 2.64Å - 2013-11-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 5H4D_H 40.3 3.0E-51 3.2Å NAD BBI 2017-11-08
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 2H4H_A 37.26 1.0E-31 1.99Å NAD 2006-09-05
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 2H4J_A 37.74 2.0E-32 2.1Å OAD NCA 2006-09-05
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 4BVE_A 40.3 2.0E-51 2.05Å - 2013-07-17
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4RMJ_B 45.06 4.0E-55 1.87Å AR6 PGE 2015-02-25
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) TP53 (P04637) HUMAN 4FZ3_A 40.3 2.0E-51 2.1Å - 2013-03-20
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 3GLU_A 40.3 2.0E-51 2.5Å - 2009-06-16
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_L 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_G 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 5H4D_A 40.3 3.0E-51 3.2Å NAD BBI 2017-11-08
Sir2 family (100%) (view alignment) HST2 (P53686) - BAKER'S YEAST 2OD2_A 39.83 4.0E-40 1.9Å CNA 2007-02-20
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5D7Q_B 45.06 4.0E-55 2.01Å AR6 4I5 2015-12-02
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 5D7N_B 40.3 2.0E-51 1.83Å - 2015-12-02
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 4BV2_A 37.74 2.0E-32 3.3Å OAD OCZ 2013-07-17
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4JSR_A 40.3 2.0E-51 1.7Å 1NQ 2013-04-24
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5MAT_C 45.06 4.0E-55 2.07Å - 2017-02-08
Sir2 family (100%) (view alignment) cobB (Q9WYW0) HHF1,HHF2 (P02309) 2H2H_A 37.74 2.0E-32 1.98Å - 2006-12-05
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4RMH_A 45.06 4.0E-55 1.42Å 3TE 2015-02-25
(view alignment) SIRT1 (Q96EB6) - HUMAN 4IG9_D 100 0 2.64Å - 2013-11-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 5YTK_C 40.3 2.0E-51 2.7Å LEU LYS 2017-12-27
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4R8M_B 42.75 9.0E-56 2.1Å - 2015-03-11
Sir2 family (100%) (view alignment) HST2 (P53686) HHF1,HHF2 (P02309) BAKER'S YEAST 1Q1A_A 40.26 2.0E-40 1.5Å OAD 2003-11-18
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4 (P62805) HUMAN 5ZGC_D 40.3 2.0E-51 2.9Å - 2019-04-03
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4JT8_A 40.3 2.0E-51 2.26Å 1NR 2013-04-24
Sir2 family (100%) (view alignment) HST2 (P53686) - BAKER'S YEAST 1Q17_C 40.26 1.0E-40 2.7Å APR 2003-11-18
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) (V9H1G0) HUMAN 5Z93_A 40.3 2.0E-51 1.945Å - 2019-02-06
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5DY5_A 45.06 4.0E-55 1.95Å EPE 5GR 2016-01-20
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 3GLS_B 40.3 2.0E-51 2.7Å - 2009-06-16
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_F 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5D7O_B 43.32 2.0E-55 1.63Å AR6 PGE 2015-12-02
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4L3O_A 43.98 4.0E-55 2.518Å MES 2014-02-19
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4JT9_A 40.3 2.0E-51 2.24Å 1NS 2013-04-24
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 5D7N_E 40.3 2.0E-51 1.83Å PGE 2015-12-02
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) RAN (P62826) HUMAN 5FYQ_B 42.53 3.0E-56 3Å - 2016-05-25
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 2H2F_A 37.74 2.0E-32 2.1Å - 2006-12-05
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4FVT_A 40.3 2.0E-51 2.47Å CNA 2012-08-15
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 5Y4H_A 40.3 2.0E-51 2.6Å 8QF 2018-05-16
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 5BTR_B 100 0 3.2Å STL 2015-07-08
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 1YC5_A 37.74 2.0E-32 1.4Å NCA 2005-04-26
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5MAR_B 45.06 4.0E-55 1.89Å AR6 7KE 2017-03-15
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4Y6Q_B 41.37 2.0E-56 1.9Å OMR 2016-01-06
Sir2 family (100%) (view alignment) HST2 (P53686) HHF1,HHF2 (P02309) BAKER'S YEAST 2QQF_A 40.26 1.0E-40 2Å A1R 2007-10-09
Sir2 family (100%) (view alignment) HST2 (P53686) HHF1,HHF2 (P02309) BAKER'S YEAST 1SZC_A 40.26 1.0E-40 1.7Å CNA 2004-06-15
Sir2 family (100%) (view alignment) cobB (Q9WYW0) - 3D81_A 37.74 2.0E-32 2.5Å - 2008-09-30
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4C7B_A 40.3 2.0E-51 2.1Å BVB 2013-11-20
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 3ZGV_B 42.53 6.0E-56 2.27Å AR6 PGE 2013-03-13
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 4BVF_A 40.3 2.0E-51 2.7Å - 2013-07-17
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) (V9H1G0) HUMAN 5Z94_A 40.3 2.0E-51 1.9Å - 2019-02-06
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 4I5I_B 100 0 2.5Å 4I5 NAD 2013-01-23
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4RMI_A 45.06 4.0E-55 1.45Å 3TK 2015-02-25
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 3ZGO_C 42.15 8.0E-55 1.63Å PGE 2013-03-20
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_H 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) TNF (P01375) HUMAN 4Y6O_A 41.37 2.0E-56 1.6Å - 2016-01-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 5YTK_E 40.3 2.0E-51 2.7Å - 2017-12-27
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 3ZGO_A 42.15 8.0E-55 1.63Å PGE 2013-03-20
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 4IG9_G 100 0 2.64Å - 2013-11-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4 (P62805) HUMAN 5ZGC_F 40.3 2.0E-51 2.9Å - 2019-04-03
Sir2 family (100%) (view alignment) (Q8I6E4) TP53 (P04637) 5OL0_A 42.08 7.0E-48 1.99Å - 2018-02-28
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_B 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
(view alignment) SIRT1 (Q96EB6) - HUMAN 4IG9_B 100 0 2.64Å - 2013-11-06
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5D7P_A 45.06 4.0E-55 1.76Å AR6 OCZ 2015-12-02
Sir2 family (100%) (view alignment) SIR2 (P06700) SIR4 (P11978) 4IAO_A 40.96 2.0E-58 2.9Å APR 2012-12-26
(view alignment) SIRT1 (Q96EB6) - HUMAN 4KXQ_B 100 0 1.849Å - 2013-10-23
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 5D7N_C 40.3 2.0E-51 1.83Å - 2015-12-02
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 6ISO_B 40.3 2.0E-51 2.95Å - 2019-01-23
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) H3F3C (Q6NXT2) HUMAN 5BWN_A 40.3 1.0E-51 1.94Å - 2016-07-13
Sir2 family (100%) (view alignment) HST2 (P53686) HHF1,HHF2 (P02309) BAKER'S YEAST 2QQG_A 40.26 1.0E-40 2.05Å A1R NCA 2007-10-09
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5G4C_B 42.53 8.0E-56 2Å CNA 2017-05-03
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 1J8F_C 42.53 8.0E-56 1.7Å - 2001-07-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BV3_A 40.3 2.0E-51 2Å OCZ APR NAD 2013-07-17
Sir2 family (100%) (view alignment) cobB (Q9WYW0) HHT1,HHT2 (P61830) 2H2G_A 37.74 2.0E-32 1.63Å - 2006-11-28
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 4KXQ_A 100 0 1.849Å APR 2013-10-23
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5YQN_A 45.06 3.0E-55 1.6Å L55 2018-10-17
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 5D7N_D 40.3 2.0E-51 1.83Å - 2015-12-02
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4Y6Q_A 41.37 2.0E-56 1.9Å OMR 2016-01-06
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5Y0Z_A 41.37 2.0E-56 1.99Å 8K9 2018-07-25
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4X3P_A 43.8 3.0E-55 1.8Å CNA 2016-01-13
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 3GLS_C 40.3 2.0E-51 2.7Å - 2009-06-16
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5D7P_B 45.06 4.0E-55 1.76Å AR6 OCZ 2015-12-02
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 4ZZH_A 100 0 3.1Å 4TO 2015-07-15
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4L3O_C 43.98 4.0E-55 2.518Å MES 2014-02-19
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 3GLS_E 40.3 2.0E-51 2.7Å - 2009-06-16
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 4C78_A 40.3 2.0E-51 2Å BVB 2013-11-20
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 4R8M_A 42.75 9.0E-56 2.1Å - 2015-03-11
Sir2 family (100%) (view alignment) HST2 (P53686) - BAKER'S YEAST 2OD9_A 40.26 1.0E-40 2.05Å A1R NCA 2007-02-27
Sir2 family (100%) (view alignment) HST2 (P53686) - BAKER'S YEAST 1Q14_A 40.26 4.0E-41 2.5Å - 2003-09-30
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4 (P62805) HUMAN 5ZGC_C 40.3 2.0E-51 2.9Å - 2019-04-03
Sir2 family (100%) (view alignment) HST2 (P53686) - BAKER'S YEAST 2OD7_A 40.26 1.0E-40 2Å A1R 2007-02-27
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 4ZZI_A 100 0 2.73Å 1NS 4TQ 2015-07-15
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5D7Q_A 45.06 4.0E-55 2.01Å AR6 4I5 2015-12-02
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) TP53 (P04637) HUMAN 4ZZJ_A 100 0 2.74Å 4TQ CNA 2015-07-15
(view alignment) SIRT1 (Q96EB6) - HUMAN 4IG9_H 100 0 2.64Å - 2013-11-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_A 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) HIST1H3A,HIST1H3B,HIST1H3C,HIST1H3D,HIST1H3E,HIST1H3F,HIST1H3G,HIST1H3H,HIST1H3I,HIST1H3J (P68431) HUMAN 4Y6L_B 41.37 2.0E-56 1.6Å - 2016-01-06
Sir2 family (100%) (view alignment) SIRT1 (Q96EB6) - HUMAN 4IG9_E 100 0 2.64Å - 2013-11-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 3GLS_A 40.3 2.0E-51 2.7Å PGE 2009-06-16
Sir2 family (100%) (view alignment) SIR2 (P06700) - BAKER'S YEAST 2HJH_A 40.96 6.0E-58 1.85Å XYQ NCA 2008-04-08
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_E 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) HIST1H4A,HIST1H4B,HIST1H4C,HIST1H4D,HIST1H4E,HIST1H4F,HIST1H4H,HIST1H4I,HIST1H4J,HIST1H4K,HIST1H4L,HIST2H4A,HIST2H4B,HIST4H4 (P62805) HUMAN 5ZGC_E 40.3 2.0E-51 2.9Å - 2019-04-03
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 5YTK_B 40.3 2.0E-51 2.7Å LEU LYS 2017-12-27
Sir2 family (100%) (view alignment) cobB (Q9WYW0) TP53 (P04637) 2H2D_A 37.74 2.0E-32 1.7Å - 2006-09-19
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BVH_C 40.3 2.0E-51 1.9Å OAD OCZ 2013-07-17
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) ACSS1 (Q9NUB1) HUMAN 4BVG_A 40.3 2.0E-51 2.5Å - 2013-07-17
Sir2 family (100%) (view alignment) SIRT2 (Q8IXJ6) - HUMAN 5Y5N_A 42.53 6.0E-56 2.3Å 8NO 2017-09-06
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 6ISO_I 40.3 2.0E-51 2.95Å - 2019-01-23
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BVB_A 40.3 2.0E-51 2Å AR6 OCZ 2013-07-17
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 4BN5_K 40.3 2.0E-51 3.25Å SR7 CNA 2013-06-26
Sir2 family (100%) (view alignment) SIRT3 (Q9NTG7) - HUMAN 5D7N_A 40.3 2.0E-51 1.83Å - 2015-12-02