Molecular Target Synopsis
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SIRT1 (Q96EB6) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 11/06/2019)
Structural Druggability Help: Help

Chain-based assessment (last updated 11/06/2019)


Chains assessed14
Chains with at least one site assessed as druggable using the strict criteria11
Chains with at least one site assessed as druggable using the relaxed criteria14


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
4I5I_A NAD-dependent protein deacetylase sirtuin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.63 72.4 44.6 Yes Yes
2 empty 2.15 68.9 28 No No
3 empty 2.22 76.9 12.2 No No
4 empty 1.85 62.3 13.8 No No
5 empty 2.57 69.3 10.6 No No
6 empty 1.73 70.9 11.5 No No
7 empty 2.45 67.2 11 No No
8 empty 2.13 64.5 10.6 No No
9 empty 2.49 66.8 9.5 No No
10 empty 1.85 61.3 8.4 No No
5BTR_C NAD-dependent protein deacetylase sirtuin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.72 66.8 46.8 Yes Yes
2 empty 1.97 62.8 29 No No
3 empty 2.14 65 24.4 No No
4 empty 1.92 58.4 18.7 No No
5 empty 2.3 61.9 23.8 No No
6 empty 2.21 51.4 12.8 No No
7 empty 1.91 55.7 18.1 No No
8 empty 2.03 61 14.1 No No
9 empty 1.6 55.4 11.8 No No
10 empty 2.09 61.4 10.3 No No
4IG9_A NAD-dependent protein deacetylase sirtuin-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.72 68.4 32.2 Yes No
2 empty 2.06 68.4 32.3 No No
3 empty 1.85 67.9 16.6 No No
4 empty 2.15 63.1 18.8 No No
5 empty 2.42 62.1 15.8 No No
6 empty 1.88 66.9 9.8 No No
7 empty 2.13 63.8 13.1 No No
8 empty 2.79 66.3 8.5 No No
9 empty 2.16 68.9 8 No No
10 empty 2.1 64.3 12.1 No No
4I5I_B NAD-dependent protein deacetylase sirtuin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.6 71.7 45.7 Yes Yes
2 empty 2.2 69.3 25.9 No No
3 empty 1.96 60.2 14.1 No No
4 empty 2.21 77.6 12.4 No No
5 empty 2.56 65 16.3 No No
6 empty 1.76 70.6 8.4 No No
7 empty 2.44 62.7 15.5 No No
8 empty 2.11 66.9 9.9 No No
9 empty 2.5 64.3 14.4 No No
10 empty 1.66 60.2 7.3 No No
4KXQ_A NAD-dependent protein deacetylase sirtuin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.09 71.5 37.5 Yes Yes
2 empty 2.17 68.3 25.7 No No
3 bound 1.94 70.8 26.8 No No
4 empty 1.81 58.2 21.2 No No
5 empty 1.69 49.4 18.5 No No
6 empty 2.18 60.2 15.4 No No
7 empty 2.34 66.1 22.4 No No
8 empty 1.85 61.7 10.9 No No
9 empty 2.33 65.5 11.4 No No
10 empty 1.44 71.3 7.8 No No
4ZZJ_A NAD-dependent protein deacetylase sirtuin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 60.4 30.7 Yes No
2 bound 1.85 93.7 0 Yes Yes
3 empty 2.29 58.9 18.4 No No
4 empty 2.12 64 15.1 No No
5 empty 1.98 52.3 19 No No
6 empty 1.97 60.4 13.2 No No
7 empty 2.35 67.6 14.3 No No
8 empty 2.09 60.4 15.3 No No
9 empty 1.62 58.4 14.2 No No
10 empty 1.84 63.8 11.1 No No
4IG9_E NAD-dependent protein deacetylase sirtuin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 67.4 37.9 Yes Yes
2 empty 2.04 67.4 32.6 No No
3 empty 2.13 64.3 25.3 No No
4 empty 2.42 61.9 20.7 No No
5 empty 2.19 62.5 15 No No
6 empty 2.08 71.8 12.8 No No
7 empty 1.8 60.3 15.3 No No
8 empty 2.24 68.1 13.2 No No
9 empty 1.92 63.8 13.3 No No
10 empty 2.4 69.9 11.1 No No
4IG9_C NAD-dependent protein deacetylase sirtuin-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.78 65.5 41.6 Yes No
2 empty 2.01 66.5 32.5 No No
3 empty 1.94 70.9 16.6 No No
4 empty 2.48 62.3 32 No No
5 empty 2.2 65 12.4 No No
6 empty 1.9 58.8 17.2 No No
7 empty 1.99 73.4 13.5 No No
8 empty 1.87 71.8 10.1 No No
9 empty 1.91 66.4 9.3 No No
10 empty 2.24 69.3 10.2 No No
4IF6_A NAD-dependent protein deacetylase sirtuin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.15 68.7 37.1 Yes Yes
2 bound 2.1 75.1 36 No No
3 empty 1.85 57.9 22.9 No No
4 empty 2.06 53 18.8 No No
5 empty 2.2 64.7 21.8 No No
6 empty 1.83 61.7 11.6 No No
7 empty 2.11 62.4 12.5 No No
8 empty 2.34 67.7 10.2 No No
9 empty 1.85 64.5 12.3 No No
10 empty 1.12 71.4 7.5 No No
5BTR_A NAD-dependent protein deacetylase sirtuin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.97 71.3 44 Yes Yes
2 empty 2.27 65.6 30.4 No No
3 empty 1.94 67.4 30.4 No No
4 empty 1.9 61.4 16.2 No No
5 empty 2.19 59.6 19.8 No No
6 empty 2.18 57.8 13 No No
7 empty 2.18 52 13.4 No No
8 empty 2.03 60.9 13.4 No No
9 empty 1.59 57.8 15 No No
10 empty 1.92 59.3 14 No No
5BTR_B NAD-dependent protein deacetylase sirtuin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.08 68.7 43.9 Yes Yes
2 empty 2.07 73.4 25.7 No No
3 empty 2.27 67 24.3 No No
4 empty 2.33 53.6 31.6 No No
5 empty 2.05 65.2 15.4 No No
6 empty 2.06 49.9 14.7 No No
7 empty 2.05 63.3 13.6 No No
8 empty 1.59 56.1 13.9 No No
9 empty 1.83 51.5 12.8 No No
10 empty 1.94 65.8 9.6 No No
4IG9_G NAD-dependent protein deacetylase sirtuin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.83 66.8 43.5 Yes Yes
2 empty 2.3 61.7 29.7 No No
3 empty 2.08 62 17.3 No No
4 empty 1.88 68 10.3 No No
5 empty 1.83 62.8 16.4 No No
6 empty 2.32 75.1 8.4 No No
7 empty 2.42 67.2 11.8 No No
8 empty 1.11 69 9.4 No No
9 empty 2.03 69 6.3 No No
10 empty 2.28 70.6 10.2 No No
4ZZH_A NAD-dependent protein deacetylase sirtuin-1 Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 1.88 64.4 32.9 Yes No
2 empty 1.56 68.8 26 No No
3 empty 1.87 67.5 17.9 No No
4 bound 1.96 47 25.8 No No
5 empty 1.71 75.6 15.4 No No
6 empty 2.15 63 17 No No
7 empty 1.81 50.5 19.1 No No
8 empty 2.21 57 13.9 No No
9 empty 1.84 63.8 10.8 No No
10 empty 1.68 60.9 11.6 No No
4ZZI_A NAD-dependent protein deacetylase sirtuin-1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.89 70.3 46.7 Yes Yes
2 empty 2.18 66.2 24.5 No No
3 empty 1.98 67.3 17.7 No No
4 empty 2.08 53.2 19 No No
5 empty 2.19 60.9 17.1 No No
6 empty 2.05 69.3 15.5 No No
7 empty 1.85 62.2 12.2 No No
8 empty 2.12 69.1 10 No No
9 empty 2.35 61 10.3 No No
10 empty 1.72 64.8 13.2 No No
Ligand-based Druggability Score: 0.45
Ligand-based Druggability Score Percentile: 84%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


SIRT1 is involved in 74 interactions in the network.


Druggability
Overall Druggability Percentile: 96.18
Druggability for Cancer Therapeutics: 97.92
Druggability for Other Therapeutics: 74.10
Cancer-Associated
Cancer-associated percentile : 99.13
Network Articulation Point
Is SIRT1 critical for communication in the network?


Detailed Graph Legend:Help