Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB3C (Q96E17) - Overview - Molecular Target Synopsis


RAB3C, Ras-related protein Rab-3C
UniProt Q96E17

Also Known as RAB3C_HUMAN, RAB3C

Protein transport. Probably involved in vesicular traffic. Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: RAB3C is active in the following subcellular-locations: cell membrane.
GO terms: RAB3C is active in the following subcellular-locations: anchored component of synaptic vesicle membrane, cytosol, endosome, perinuclear region of cytoplasm, plasma membrane, synaptic vesicle, vesicle.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB3C has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: CAKI_1, ACHN, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1355, SK-N-FI, COR-L47

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 75% identity similarity to RAB3C there are:
5 structures (6 chains) solved
5 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAB3C has been screened with compounds ( bioactivities). (see details)