Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB3C (Q96E17) - Overview - Molecular Target Synopsis

Protein


RAB3C, Ras-related protein Rab-3C
UniProt Q96E17

Also Known as RAB3C_HUMAN, RAB3C

Protein transport. Probably involved in vesicular traffic. Interacts with RIMS1, RIMS2, RPH3A and RPH3AL.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
227ENSG00000152932ENST00000282878ENSP00000282878Q96E17-1

Sub-cellular localization


UniProt: RAB3C is active in the following subcellular-locations: cell membrane.
GO terms: RAB3C is active in the following subcellular-locations: anchored component of synaptic vesicle membrane, cytosol, endosome, perinuclear region of cytoplasm, plasma membrane, synaptic vesicle, vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB3C has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CAKI_1, ACHN, NCI_ADR_RES

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1355, SK-N-FI, COR-L47

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 75% identity similarity to RAB3C there are:
5 structures (6 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB3C has been screened with compounds ( bioactivities). (see details)