Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MTBP (Q96DY7) - Overview - Molecular Target Synopsis

Protein


MTBP, Mdm2-binding protein
UniProt Q96DY7

Also Known as MTBP_HUMAN, MTBP

Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Interacts with MDM2.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: MTBP is active in the following subcellular-locations: chromatin, kinetochore.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MTBP has gain in 40 cell-lines, loss in 0 cell-lines and no signal in 965 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, HT29, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HGC-27, HEY, KP4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)