Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

MTBP (Q96DY7) - Overview - Molecular Target Synopsis


MTBP, Mdm2-binding protein
UniProt Q96DY7

Also Known as MTBP_HUMAN, MTBP

Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Interacts with MDM2.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

GO terms: MTBP is active in the following subcellular-locations: chromatin, kinetochore.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project MTBP has gain in 40 cell-lines, loss in 0 cell-lines and no signal in 965 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: NCI_H522, HT29, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HGC-27, HEY, KP4

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)