MTBP (Q96DY7) - Overview - Molecular Target Synopsis
MTBP, Mdm2-binding protein
Also Known as MTBP_HUMAN, MTBP
Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation. Interacts with MDM2.
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GO terms: MTBP is active in the following subcellular-locations: chromatin, kinetochore.