Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ERP27 (Q96DN0) - Overview - Molecular Target Synopsis

Protein


ERP27, Endoplasmic reticulum resident protein 27
UniProt Q96DN0

Also Known as ERP27_HUMAN, ERP27, C12orf46

Interacts with PDIA3. Binds somatostatin-14 via hydrophobic interactions.

4F9Z
CRYSTAL STRUCTURE OF HUMAN ERP27
RCSB/PDB
Inspect Structure
See all 3D Structures for ERP27

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
273ENSG00000139055ENST00000266397ENSP00000266397Q96DN0-1
172ENSG00000139055ENST00000540097ENSP00000440573

Sub-cellular localization


UniProt: ERP27 is active in the following subcellular-locations: endoplasmic reticulum lumen.
GO terms: ERP27 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum lumen.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ERP27 has gain in 7 cell-lines, loss in 4 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, OVCAR_4, OVCAR_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OAW28, RT4, CAL-85-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For ERP27 there are:
2 structures (6 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis