Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

OTUB2 (Q96DC9) - Overview - Molecular Target Synopsis

Protein


OTUB2, Ubiquitin thioesterase OTUB2
Enzyme Classification 3.4.19.12
UniProt Q96DC9

Also Known as OTUB2_HUMAN, OTUB2, C14orf137, OTB2, OTU2

Hydrolase that can remove conjugated ubiquitin from proteins in vitro and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. Mediates deubiquitination of 'Lys-11'-,'Lys-48'- and 'Lys-63'-linked polyubiquitin chains, with a preference for 'Lys-63'-linked polyubiquitin chains.

4FJV
CRYSTAL STRUCTURE OF HUMAN OTUBAIN2 AND UBIQUITIN COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for OTUB2

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
234ENSG00000089723ENST00000203664ENSP00000203664Q96DC9-1
73ENSG00000089723ENST00000553723ENSP00000451283Q96DC9-2

Sub-cellular localization


GO terms: OTUB2 is active in the following subcellular-locations: nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project OTUB2 has gain in 5 cell-lines, loss in 3 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: OVCAR_5, CAKI_1, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: JHH-4, SK-CO-1, HCC515

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For OTUB2 there are:
2 structures (3 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis