Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB39B (Q96DA2) - Overview - Molecular Target Synopsis

Protein


RAB39B, Ras-related protein Rab-39B
UniProt Q96DA2

Also Known as RB39B_HUMAN, RAB39B

Small GTPases Rab involved in autophagy (PubMed:27103069). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27103069). May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission. Interacts (in GTP-bound form) with PICK1 (via PDZ domain); a PICK1 homodimer may allow simultaneous association of RAB39B and GRIA2 to PICK1 which is involved in GRIA2 trafficking.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
213ENSG00000155961ENST00000369454ENSP00000358466Q96DA2-1

Sub-cellular localization


UniProt: RAB39B is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle membrane, golgi apparatus.
GO terms: RAB39B is active in the following subcellular-locations: cytoplasmic vesicle membrane, Golgi apparatus, intracellular, neuron projection, plasma membrane, vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB39B has gain in 2 cell-lines, loss in 19 cell-lines and no signal in 984 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MOLT_4, TK_10, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, HCC12, L-363

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 50% identity similarity to RAB39B there are:
5 structures (16 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB39B has been screened with compounds ( bioactivities). (see details)