Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

RAB39B (Q96DA2) - Overview - Molecular Target Synopsis


RAB39B, Ras-related protein Rab-39B
UniProt Q96DA2

Also Known as RB39B_HUMAN, RAB39B

Small GTPases Rab involved in autophagy (PubMed:27103069). The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:27103069). May regulate the homeostasis of SNCA/alpha-synuclein. Together with PICK1 proposed to ensure selectively GRIA2 exit from the endoplasmic reticulum to the Golgi and to regulate AMPAR compostion at the post-synapses and thus synaptic transmission. Interacts (in GTP-bound form) with PICK1 (via PDZ domain); a PICK1 homodimer may allow simultaneous association of RAB39B and GRIA2 to PICK1 which is involved in GRIA2 trafficking.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: RAB39B is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle membrane, golgi apparatus.
GO terms: RAB39B is active in the following subcellular-locations: cytoplasmic vesicle membrane, Golgi apparatus, intracellular, neuron projection, plasma membrane, vesicle.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project RAB39B has gain in 2 cell-lines, loss in 19 cell-lines and no signal in 984 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: MOLT_4, TK_10, HS578T

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, HCC12, L-363

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 50% identity similarity to RAB39B there are:
5 structures (16 chains) solved
5 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

RAB39B has been screened with compounds ( bioactivities). (see details)