Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

COQ8B (Q96D53) - Overview - Molecular Target Synopsis


COQ8B, Atypical kinase COQ8B, mitochondrial
Enzyme Classification 2.7.-.-
UniProt Q96D53

Also Known as COQ8B_HUMAN, COQ8B, ADCK4

Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration (PubMed:24270420). Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration (PubMed:24270420). Homodimer; homodimerizes via its transmembrane region (PubMed:25216398). Interacts with COQ6 and COQ7 (PubMed:24270420). Interacts with the multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9 (PubMed:27499296).

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: COQ8B is active in the following subcellular-locations: cell membrane, cytoplasm, cytosol, mitochondrion membrane.
GO terms: COQ8B is active in the following subcellular-locations: cytosol, extrinsic component of mitochondrial inner membrane, integral component of membrane, mitochondrion, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project COQ8B has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are:

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are:

(see details)

RNA Interference

COQ8B was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: COV504, LM7. (see details)

3D Structures

At greater than 50% identity similarity to COQ8B there are:
2 structures (2 chains) solved
1 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

COQ8B has been screened with 117 compounds (175 bioactivities), 5 compounds have bioactivities that show binding affinity of <= 500nM (5 bioactivities). (see details)