Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ACSF2 (Q96CM8) - Overview - Molecular Target Synopsis

Protein


ACSF2, Acyl-CoA synthetase family member 2, mitochondrial
Enzyme Classification 6.2.1.-
UniProt Q96CM8

Also Known as ACSF2_HUMAN, ACSF2

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ACSF2 is active in the following subcellular-locations: mitochondrion.
GO terms: ACSF2 is active in the following subcellular-locations: mitochondrial matrix.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ACSF2 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, OVCAR_4, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVKATE, ChaGo-K-1, NCI-H1781

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, NHEK

(see details)