Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NSUN4 (Q96CB9) - Overview - Molecular Target Synopsis

Protein


NSUN4, 5-methylcytosine rRNA methyltransferase NSUN4
Enzyme Classification 2.1.1.-
UniProt Q96CB9

Also Known as NSUN4_HUMAN, NSUN4

Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.

4FZV
CRYSTAL STRUCTURE OF THE HUMAN MTERF4:NSUN4:SAM TERNARY COMPLEX
RCSB/PDB
Inspect Structure
See all 3D Structures for NSUN4

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NSUN4 is active in the following subcellular-locations: mitochondrion.
GO terms: NSUN4 is active in the following subcellular-locations: mitochondrial large ribosomal subunit, mitochondrial matrix.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NSUN4 has gain in 2 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: TK_10, K_562, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 53, G112, HEL

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, SK-N-SH, K562

(see details)

3D Structures


For NSUN4 there are:
2 structures (5 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis