Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ULK4 (Q96C45) - Overview - Molecular Target Synopsis

Protein


ULK4, Serine/threonine-protein kinase ULK4
Enzyme Classification 2.7.11.1
UniProt Q96C45

Also Known as ULK4_HUMAN, ULK4

May be involved in the remodeling of cytoskeletal components, such as alpha-tubulin, and in this way regulates neurite branching and elongation, as well as cell motility.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1275ENSG00000168038ENST00000301831ENSP00000301831Q96C45-1
580ENSG00000168038ENST00000420927ENSP00000412187

Gene Copy Number Variation


In COSMIC - Cell Lines Project ULK4 has gain in 1 cell-lines, loss in 5 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_2, MCF7, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: 888, NIH:OVCAR-3, RMG-I

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHLF, A549

(see details)

RNA Interference


ULK4 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: OVISE, SCC90. (see details)