Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

GALM (Q96C23) - Overview - Molecular Target Synopsis

Protein


GALM, Aldose 1-epimerase
Enzyme Classification 5.1.3.3
UniProt Q96C23

Also Known as GALM_HUMAN, GALM

Mutarotase converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose. Monomer.

1SNZ
CRYSTAL STRUCTURE OF APO HUMAN GALACTOSE MUTAROTASE
RCSB/PDB
Inspect Structure
See all 3D Structures for GALM

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: GALM is active in the following subcellular-locations: cytoplasm.
GO terms: GALM is active in the following subcellular-locations: cytoplasm, extracellular exosome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project GALM has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, COLO205, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SR-786, SU-DHL-1, SR

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, NHLF, HeLa-S3

(see details)

3D Structures


For GALM there are:
2 structures (6 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis