Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TBC1D20 (Q96BZ9) - Overview - Molecular Target Synopsis

Protein


TBC1D20, TBC1 domain family member 20
UniProt Q96BZ9

Also Known as TBC20_HUMAN, TBC1D20, C20orf140

GTPase-activating protein specific for Rab1 and Rab2 small GTPase families for which it can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude. (Microbial infection) Directly interacts with the N-terminal amphipathic helix of hepatitis C virus (HCV) NS5A.

4HL4
CRYSTAL STRUCTURE OF THE HUMAN TBC1D20 RABGAP DOMAIN
RCSB/PDB
Inspect Structure
See all 3D Structures for TBC1D20

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
428Q96BZ9-3
403ENSG00000125875ENST00000461304, ENST00000354200ENSP00000432280, ENSP00000346139Q96BZ9-1
172Q96BZ9-2

Sub-cellular localization


UniProt: TBC1D20 is active in the following subcellular-locations: membrane.
GO terms: TBC1D20 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, endoplasmic reticulum-Golgi intermediate compartment membrane, integral component of Golgi membrane, nuclear membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TBC1D20 has gain in 1 cell-lines, loss in 3 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SK_MEL_28, UACC_257, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KYSE-70, DMS 454, M059J

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For TBC1D20 there are:
2 structures (6 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis