Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PLD4 (Q96BZ4) - Overview - Molecular Target Synopsis

Protein


PLD4, Phospholipase D4
Enzyme Classification 3.1.4.4
UniProt Q96BZ4

Also Known as PLD4_HUMAN, PLD4, C14orf175

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PLD4 is active in the following subcellular-locations: membrane.
GO terms: PLD4 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, integral component of membrane, nucleus, phagocytic vesicle, trans-Golgi network membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PLD4 has gain in 5 cell-lines, loss in 2 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RPMI_8226, HS578T, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: THP-1, OPM-2, OCI-LY-10

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD20-positive B cell, SK-N-SH, NHLF

(see details)


Screening and Chemistry


PLD4 has been screened with compounds ( bioactivities). (see details)