Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ATG2B (Q96BY7) - Overview - Molecular Target Synopsis

Protein


ATG2B, Autophagy-related protein 2 homolog B
UniProt Q96BY7

Also Known as ATG2B_HUMAN, ATG2B, C14orf103

Required for both autophagosome formation and regulation of lipid droplet morphology and dispersion.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
2078ENSG00000066739ENST00000359933ENSP00000353010Q96BY7-1

Sub-cellular localization


UniProt: ATG2B is active in the following subcellular-locations: lipid droplet, preautophagosomal structure membrane.
GO terms: ATG2B is active in the following subcellular-locations: extrinsic component of membrane, lipid droplet, nucleoplasm, phagophore assembly site, phagophore assembly site membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ATG2B has gain in 5 cell-lines, loss in 3 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_268, SR, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: FaDu, Hs 746T, EJM

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)