Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

CHCHD1 (Q96BP2) - Overview - Molecular Target Synopsis


CHCHD1, Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
UniProt Q96BP2

Also Known as CHCH1_HUMAN, CHCHD1, C10orf34, MRPS37

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

UniProt: CHCHD1 is active in the following subcellular-locations: mitochondrion, nucleus.
GO terms: CHCHD1 is active in the following subcellular-locations: cytosol, fibrillar center, mitochondrial inner membrane, mitochondrial ribosome, mitochondrion, nucleoplasm.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project CHCHD1 has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: PC_3, K_562, OVCAR_8

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MFM-223, PC-3, SK-BR-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, A549, SK-N-SH

(see details)

3D Structures

At greater than 75% identity similarity to CHCHD1 there are:
4 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis