Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CHCHD1 (Q96BP2) - Overview - Molecular Target Synopsis

Protein


CHCHD1, Coiled-coil-helix-coiled-coil-helix domain-containing protein 1
UniProt Q96BP2

Also Known as CHCH1_HUMAN, CHCHD1, C10orf34, MRPS37

Component of the mitochondrial small ribosomal subunit (mt-SSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
118ENSG00000172586ENST00000372833ENSP00000361923Q96BP2-1
97ENSG00000172586ENST00000372837ENSP00000361928

Sub-cellular localization


UniProt: CHCHD1 is active in the following subcellular-locations: mitochondrion, nucleus.
GO terms: CHCHD1 is active in the following subcellular-locations: cytosol, fibrillar center, mitochondrial inner membrane, mitochondrial ribosome, mitochondrion, nucleoplasm.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CHCHD1 has gain in 5 cell-lines, loss in 1 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, K_562, OVCAR_8

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MFM-223, PC-3, SK-BR-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HeLa-S3, A549, SK-N-SH

(see details)

3D Structures


At greater than 75% identity similarity to CHCHD1 there are:
4 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis