Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
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Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL8A (Q96BM9) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 23/04/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 23/04/2019)


Chains assessed3
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria2


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
1ZD9_A ADP-ribosylation factor-like protein 8A Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.33 78.9 21.5 Yes Yes
2 empty 2.59 63.1 17.6 No No
3 empty 2.52 64.6 14.9 No No
4 empty 2.89 65.5 13.8 No No
5 empty 2.18 62.3 10.4 No No
6 empty 2.41 72.7 9.8 No No
7 empty 2.49 65.9 9.3 No No
8 empty 2.33 64.7 8.2 No No
9 empty 1.81 67.6 6.4 No No
10 empty 2.08 64.1 7.8 No No
2H18_A ADP-ribosylation factor-like protein 8A Yes No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.22 62.4 24.9 Yes No
2 empty 2.32 69.5 11.6 No No
3 empty 1.82 77.6 11.7 No No
4 empty 2.52 55.4 14 No No
5 empty 2.06 62.5 11.8 No No
6 bound 1.83 74.8 8.4 No No
7 empty 2.42 61.5 15.9 No No
8 empty 2.27 59.7 10.7 No No
9 empty 2.44 61.8 9.6 No No
10 empty 2.79 81.5 0 No No
4ILE_A ADP-ribosylation factor-like protein 8A No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 2.14 66.2 22.1 No No
2 empty 2.23 61.5 15.1 No No
3 empty 2.43 62 15.7 No No
4 empty 2.06 67.8 14.2 No No
5 empty 2.36 56.5 16.9 No No
6 empty 2.57 58.8 14.5 No No
7 empty 1.9 62.2 10.8 No No
8 empty 2.53 66.1 9.4 No No
9 empty 2.35 69.4 8.4 No No
10 empty 2.39 56.9 12.1 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria1
Domains assessed as druggable using the relaxed criteria2

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
1ZD9_A (124938) ADP-ribosylation factor-like protein 8A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, G proteins 1.7Å Yes Yes
2H18_A (3100620) ADP-ribosylation factor-like protein 8A P-loop containing nucleoside triphosphate hydrolases, P-loop containing nucleoside triphosphate hydrolases, UNMATCHED 1.9Å Yes No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


ARL8A is involved in 2 interactions in the network.


Druggability
Overall Druggability Percentile: 44.45
Druggability for Cancer Therapeutics: 46.53
Druggability for Other Therapeutics: 4.73
Cancer-Associated
Cancer-associated percentile : 23.43
Network Articulation Point
Is ARL8A critical for communication in the network?


Detailed Graph Legend:Help