Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL8A (Q96BM9) - Overview - Molecular Target Synopsis

Protein


ARL8A, ADP-ribosylation factor-like protein 8A
UniProt Q96BM9

Also Known as ARL8A_HUMAN, ARL8A, ARL10B, GIE2

Plays a role in lysosome motility (By similarity). In neurons, mediates the anterograde axonal long-range transport of presynaptic lysosome-related vesicles required for presynaptic biogenesis and synaptic function (By similarity). May play a role in chromosome segregation.

4ILE
STRUCTURE OF HUMAN ADP-RIBOSYLATION FACTOR-LIKE 8A BINDING TO GDP
RCSB/PDB
Inspect Structure
See all 3D Structures for ARL8A

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
186ENSG00000143862ENST00000272217ENSP00000272217Q96BM9-1

Sub-cellular localization


UniProt: ARL8A is active in the following subcellular-locations: axon, cell junction, cell projection, cytoplasm, cytoskeleton, late endosome membrane, lysosome membrane, spindle, synapse.
GO terms: ARL8A is active in the following subcellular-locations: axon cytoplasm, azurophil granule membrane, cytoplasm, extracellular exosome, ficolin-1-rich granule membrane, late endosome membrane, lysosomal membrane, membrane, midbody, plasma membrane, spindle midzone, vacuolar membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL8A has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H522, SNB_75, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SK-N-FI, NCI-H196, HCC12

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


For ARL8A there are:
3 structures (3 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis