Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

AIDA (Q96BJ3) - Overview - Molecular Target Synopsis

Protein


AIDA, Axin interactor, dorsalization-associated protein
UniProt Q96BJ3

Also Known as AIDA_HUMAN, AIDA, C1orf80

Acts as a ventralizing factor during embryogenesis. Inhibits axin-mediated JNK activation by binding axin and disrupting axin homodimerization. This in turn antagonizes a Wnt/beta-catenin-independent dorsalization pathway activated by AXIN/JNK-signaling (By similarity). Interacts with AXIN1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


GO terms: AIDA is active in the following subcellular-locations: cytoplasm, membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project AIDA has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HS578T, TK_10, CAKI_1

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LNCAP, MDA-MB-157, HCC38

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

3D Structures


At greater than 90% identity similarity to AIDA there are:
3 structures (4 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis