Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLCO4A1 (Q96BD0) - Overview - Molecular Target Synopsis

Protein


SLCO4A1, Solute carrier organic anion transporter family member 4A1
UniProt Q96BD0

Also Known as SO4A1_HUMAN, SLCO4A1, OATP1, OATP4A1, OATPE, SLC21A12

Mediates the Na(+)-independent transport of organic anions such as the thyroid hormones T3 (triiodo-L-thyronine), T4 (thyroxine) and rT3, and of estrone-3-sulfate and taurocholate.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLCO4A1 is active in the following subcellular-locations: cell membrane.
GO terms: SLCO4A1 is active in the following subcellular-locations: integral component of plasma membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLCO4A1 has gain in 9 cell-lines, loss in 1 cell-lines and no signal in 995 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, OVCAR_5, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC1171, SNU-5, HCC366

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, HeLa-S3, SK-N-SH

(see details)


Screening and Chemistry


SLCO4A1 has been screened with 11 compounds (14 bioactivities). (see details)