Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB37 (Q96AX2) - Overview - Molecular Target Synopsis

Protein


RAB37, Ras-related protein Rab-37
UniProt Q96AX2

Also Known as RAB37_HUMAN, RAB37

Interacts with RIMS1.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB37 is active in the following subcellular-locations: cytoplasmic vesicle.
GO terms: RAB37 is active in the following subcellular-locations: azurophil granule membrane, endoplasmic reticulum-Golgi intermediate compartment, plasma membrane, specific granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB37 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: CCRF_CEM, MOLT_4, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HEL, KG-1, YAPC

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: CD34-positive mobilized cell, SK-N-SH, NHLF

(see details)

3D Structures


At greater than 75% identity similarity to RAB37 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB37 has been screened with compounds ( bioactivities). (see details)