APOBEC3D (Q96AK3) - Overview - Molecular Target Synopsis
APOBEC3D, DNA dC->dU-editing enzyme APOBEC-3D
Enzyme Classification 18.104.22.168
Also Known as ABC3D_HUMAN, APOBEC3D
DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|386||ENSG00000243811||ENST00000381568, ENST00000216099||ENSP00000370980, ENSP00000216099||Q96AK3-1|
UniProt: APOBEC3D is active in the following subcellular-locations: cytoplasm, p-body.
GO terms: APOBEC3D is active in the following subcellular-locations: cytoplasm, nucleus, P-body.