Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

APOBEC3D (Q96AK3) - Overview - Molecular Target Synopsis


APOBEC3D, DNA dC->dU-editing enzyme APOBEC-3D
Enzyme Classification
UniProt Q96AK3


DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
386ENSG00000243811ENST00000381568, ENST00000216099ENSP00000370980, ENSP00000216099Q96AK3-1

Sub-cellular localization

UniProt: APOBEC3D is active in the following subcellular-locations: cytoplasm, p-body.
GO terms: APOBEC3D is active in the following subcellular-locations: cytoplasm, nucleus, P-body.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project APOBEC3D has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KMS-21BM, COR-L26, LP-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures

At greater than 75% identity similarity to APOBEC3D there are:
11 structures (30 chains) solved
0 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

APOBEC3D has been screened with compounds ( bioactivities). (see details)