Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

APOBEC3D (Q96AK3) - Overview - Molecular Target Synopsis

Protein


APOBEC3D, DNA dC->dU-editing enzyme APOBEC-3D
Enzyme Classification 3.5.4.38
UniProt Q96AK3

Also Known as ABC3D_HUMAN, APOBEC3D

DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. May inhibit the mobility of LTR and non-LTR retrotransposons.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
386ENSG00000243811ENST00000381568, ENST00000216099ENSP00000370980, ENSP00000216099Q96AK3-1
202ENSG00000243811ENST00000427494ENSP00000388017

Sub-cellular localization


UniProt: APOBEC3D is active in the following subcellular-locations: cytoplasm, p-body.
GO terms: APOBEC3D is active in the following subcellular-locations: cytoplasm, nucleus, P-body.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project APOBEC3D has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: KMS-21BM, COR-L26, LP-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HSMM, NHLF

(see details)

3D Structures


At greater than 75% identity similarity to APOBEC3D there are:
11 structures (30 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


APOBEC3D has been screened with compounds ( bioactivities). (see details)