Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB7B (Q96AH8) - Overview - Molecular Target Synopsis

Protein


RAB7B, Ras-related protein Rab-7b
UniProt Q96AH8

Also Known as RAB7B_HUMAN, RAB7B

Controls vesicular trafficking from endosomes to the trans-Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation pathway.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
199Q96AH8-1

Sub-cellular localization


UniProt: RAB7B is active in the following subcellular-locations: cytoplasmic vesicle, golgi apparatus, late endosome, lysosome, phagosome, phagosome membrane, trans-golgi network.
GO terms: RAB7B is active in the following subcellular-locations: Golgi apparatus, late endosome, late endosome membrane, lysosome, phagocytic vesicle, phagocytic vesicle membrane, trans-Golgi network, vacuolar membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB7B has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SNB_75, HL_60, SF_539

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HNT-34, Hs 695T, NCI-H2596

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HMEC, NHLF, NHEK

(see details)

3D Structures


At greater than 50% identity similarity to RAB7B there are:
4 structures (9 chains) solved
4 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB7B has been screened with compounds ( bioactivities). (see details)