Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RERG (Q96A58) - Overview - Molecular Target Synopsis

Protein


RERG, Ras-related and estrogen-regulated growth inhibitor
UniProt Q96A58

Also Known as RERG_HUMAN, RERG

Binds GDP/GTP and possesses intrinsic GTPase activity. Has higher affinity for GDP than for GTP. In cell lines overexpression leads to a reduction in the rate of proliferation, colony formation and in tumorigenic potential.

2ATV
THE CRYSTAL STRUCTURE OF HUMAN RERG IN THE GDP BOUND STATE
RCSB/PDB
Inspect Structure
See all 3D Structures for RERG

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RERG is active in the following subcellular-locations: cytoplasm.
GO terms: RERG is active in the following subcellular-locations: cytosol, membrane, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RERG has gain in 7 cell-lines, loss in 5 cell-lines and no signal in 993 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: T47D, MCF7, TK_10

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-134-VI, HCC1187, NCI-H1581

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: MCF-7, SK-N-SH, NHLF

(see details)

3D Structures


For RERG there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RERG has been screened with compounds ( bioactivities). (see details)