Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ADIPOR1 (Q96A54) - Overview - Molecular Target Synopsis

Protein


ADIPOR1, Adiponectin receptor protein 1
UniProt Q96A54

Also Known as PAQR1_HUMAN, ADIPOR1, PAQR1, TESBP1A

Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:25855295, PubMed:12802337). Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. May form homooligomers and heterooligomers with ADIPOR2 (PubMed:12802337). Interacts with APPL2 (via BAR domain); hinders the accessibility of APPL1 to ADIPOR1; negatively regulates adiponectin signaling; ADIPOQ dissociates this interaction and facilitates the recruitment of APPL1 to ADIPOR1. Interacts with APPL1; ADIPOQ enhances this interaction; inhibites adiponectin-stimulated binding of APPL2 to ADIPOR1.

5LXG
REVISED CRYSTAL STRUCTURE OF THE HUMAN ADIPONECTIN RECEPTOR 1 IN AN OPEN CONFORMATION
RCSB/PDB
Inspect Structure
See all 3D Structures for ADIPOR1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: ADIPOR1 is active in the following subcellular-locations: cell membrane.
GO terms: ADIPOR1 is active in the following subcellular-locations: integral component of membrane, intrinsic component of plasma membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ADIPOR1 has gain in 2 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_MEL_5, MALME_3M

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: DMS 53, C32, NCI-H1781

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: HSMM, NHEK, HeLa-S3

(see details)

3D Structures


For ADIPOR1 there are:
2 structures (2 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis