Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RELT (Q969Z4) - Overview - Molecular Target Synopsis

Protein


RELT, Tumor necrosis factor receptor superfamily member 19L
UniProt Q969Z4

Also Known as TR19L_HUMAN, RELT, TNFRSF19L

May play a role in apoptosis (PubMed:28688764, PubMed:19969290). Induces activation of MAPK14/p38 and MAPK8/JNK MAPK cascades, when overexpressed (PubMed:16530727). Interacts with TRAF1 (PubMed:11313261). Interacts with RELL1, RELL2 and OXSR1 (PubMed:16389068). Interacts with PLSCR1 (PubMed:22052202). Interacts with STK39 (PubMed:16530727).

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RELT is active in the following subcellular-locations: cell membrane, cytoplasm, perinuclear region.
GO terms: RELT is active in the following subcellular-locations: integral component of membrane, nucleus, perinuclear region of cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RELT has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SR, HCT_116, 786_0

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: UKE-1, HEL, EPLC-272H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: K562, CD20-positive B cell, CD14-positive monocyte

(see details)