Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TMBIM1 (Q969X1) - Overview - Molecular Target Synopsis

Protein


TMBIM1, Protein lifeguard 3
UniProt Q969X1

Also Known as LFG3_HUMAN, TMBIM1, LFG3, RECS1

Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: TMBIM1 is active in the following subcellular-locations: endosome membrane, lysosome membrane, membrane.
GO terms: TMBIM1 is active in the following subcellular-locations: endosome membrane, extracellular exosome, Golgi apparatus, integral component of membrane, intracellular membrane-bounded organelle, lysosomal membrane, plasma membrane, specific granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TMBIM1 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: NCI_H322M, HT29, KM12

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COV434, Panc 05.04, Capan-2

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHEK, HMEC, NHLF

(see details)


Screening and Chemistry


TMBIM1 has been screened with compounds ( bioactivities). (see details)