NEIL2 (Q969S2) - Overview - Molecular Target Synopsis
NEIL2, Endonuclease 8-like 2
Enzyme Classification 3.2.2.-
Also Known as NEIL2_HUMAN, NEIL2
Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Binds EP300.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|332||ENSG00000154328||ENST00000455213, ENST00000284503, ENST00000436750||ENSP00000397538, ENSP00000284503, ENSP00000394023||Q969S2-1|
UniProt: NEIL2 is active in the following subcellular-locations: nucleus.
GO terms: NEIL2 is active in the following subcellular-locations: cytoplasm, intracellular membrane-bounded organelle, nucleoplasm, nucleus, spindle microtubule.