Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

NEIL2 (Q969S2) - Overview - Molecular Target Synopsis


NEIL2, Endonuclease 8-like 2
Enzyme Classification 3.2.2.-
UniProt Q969S2

Also Known as NEIL2_HUMAN, NEIL2

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Binds EP300.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: NEIL2 is active in the following subcellular-locations: nucleus.
GO terms: NEIL2 is active in the following subcellular-locations: cytoplasm, intracellular membrane-bounded organelle, nucleoplasm, nucleus, spindle microtubule.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project NEIL2 has gain in 2 cell-lines, loss in 14 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: LOXIMVI, BT_549, DU_145

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC12, C-33 A, DAN-G

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HSMM

(see details)