Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

NEIL2 (Q969S2) - Overview - Molecular Target Synopsis

Protein


NEIL2, Endonuclease 8-like 2
Enzyme Classification 3.2.2.-
UniProt Q969S2

Also Known as NEIL2_HUMAN, NEIL2

Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Binds EP300.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: NEIL2 is active in the following subcellular-locations: nucleus.
GO terms: NEIL2 is active in the following subcellular-locations: cytoplasm, intracellular membrane-bounded organelle, nucleoplasm, nucleus, spindle microtubule.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project NEIL2 has gain in 2 cell-lines, loss in 14 cell-lines and no signal in 989 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: LOXIMVI, BT_549, DU_145

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC12, C-33 A, DAN-G

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, HSMM

(see details)