Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB24 (Q969Q5) - Overview - Molecular Target Synopsis

Protein


RAB24, Ras-related protein Rab-24
UniProt Q969Q5

Also Known as RAB24_HUMAN, RAB24

May be involved in autophagy-related processes. Unlike other Rab family members, does not interact with GDP dissociation inhibitors (GDIs), including ARHGDIA and ARHGDIB. Interacts with ZFYVE20.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB24 is active in the following subcellular-locations: cytoplasm, cytosol, membrane.
GO terms: RAB24 is active in the following subcellular-locations: autophagosome, cytosol, endocytic vesicle, endosome, plasma membrane, secretory granule membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB24 has gain in 2 cell-lines, loss in 2 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, NCI_H522, SK_MEL_2

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVISE, HEL, NCI-H929

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, K562, A549

(see details)

3D Structures


At greater than 35% identity similarity to RAB24 there are:
53 structures (91 chains) solved
48 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB24 has been screened with compounds ( bioactivities). (see details)