Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ARL11 (Q969Q4) - Overview - Molecular Target Synopsis

Protein


ARL11, ADP-ribosylation factor-like protein 11
UniProt Q969Q4

Also Known as ARL11_HUMAN, ARL11, ARLTS1

May play a role in apoptosis. May act as a tumor suppressor.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
202ENSG00000152213ENST00000282026ENSP00000282026
196Q969Q4-1

Sub-cellular localization


GO terms: ARL11 is active in the following subcellular-locations: cytoplasm, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ARL11 has gain in 2 cell-lines, loss in 9 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, SUP-B15, SKM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 35% identity similarity to ARL11 there are:
92 structures (195 chains) solved
81 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ARL11 has been screened with compounds ( bioactivities). (see details)