Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

ARL11 (Q969Q4) - Overview - Molecular Target Synopsis


ARL11, ADP-ribosylation factor-like protein 11
UniProt Q969Q4

Also Known as ARL11_HUMAN, ARL11, ARLTS1

May play a role in apoptosis. May act as a tumor suppressor.

Isoforms / Transcripts (Protein Coding)

Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform

Sub-cellular localization

GO terms: ARL11 is active in the following subcellular-locations: cytoplasm, plasma membrane.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project ARL11 has gain in 2 cell-lines, loss in 9 cell-lines and no signal in 994 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WSU-FSCCL, SUP-B15, SKM-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures

At greater than 35% identity similarity to ARL11 there are:
92 structures (195 chains) solved
81 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

ARL11 has been screened with compounds ( bioactivities). (see details)