Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TRIM63 (Q969Q1) - Overview - Molecular Target Synopsis

Protein


TRIM63, E3 ubiquitin-protein ligase TRIM63
Enzyme Classification 2.3.2.27
UniProt Q969Q1

Also Known as TRI63_HUMAN, TRIM63, IRF, MURF1, RNF28, SMRZ

E3 ubiquitin ligase. Mediates the ubiquitination and subsequent proteasomal degradation of CKM, GMEB1 and HIBADH. Regulates the proteasomal degradation of muscle proteins under amino acid starvation, where muscle protein is catabolized to provide other organs with amino acids. Inhibits de novo skeletal muscle protein synthesis under amino acid starvation. Regulates proteasomal degradation of cardiac troponin I/TNNI3 and probably of other sarcomeric-associated proteins. May play a role in striated muscle atrophy and hypertrophy by regulating an anti-hypertrophic PKC-mediated signaling pathway. May regulate the organization of myofibrils through TTN in muscle cells. Homodimer. Homooligomer and heterooligomer. Interacts with SUMO2, titin/TTN and GMEB1. Interacts with TRIM54 and probably with TRIM55 and TNNI3. Forms a ternary complex with RACK1 and PRKCE (By similarity). Interacts with CKM.

4M3L
CRYSTAL STRUCTURE OF THE COILED COIL DOMAIN OF MURF1
RCSB/PDB
Inspect Structure
See all 3D Structures for TRIM63

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
353ENSG00000158022ENST00000374272ENSP00000363390Q969Q1-1
325Q969Q1-2

Sub-cellular localization


UniProt: TRIM63 is active in the following subcellular-locations: cytoplasm, m line, myofibril, nucleus, sarcomere, z line.
GO terms: TRIM63 is active in the following subcellular-locations: cytoplasm, M band, microtubule, nucleus, Z disc.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TRIM63 has gain in 0 cell-lines, loss in 1 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: UACC_257, SK_MEL_5, SK_MEL_28

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MeWo, UACC-257, SK-MEL-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For TRIM63 there are:
3 structures (8 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis