Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MR1 (Q95460) - Overview - Molecular Target Synopsis

Protein


MR1, Major histocompatibility complex class I-related gene protein
UniProt Q95460

Also Known as HMR1_HUMAN, MR1

Antigen-presenting molecule specialized in presenting microbial vitamin B metabolites. Involved in the development and expansion of a small population of T-cells expressing an invariant T-cell receptor alpha chain called mucosal-associated invariant T-cells (MAIT). MAIT lymphocytes are preferentially located in the gut lamina propria and therefore may be involved in monitoring commensal flora or serve as a distress signal. Expression and MAIT cell recognition seem to be ligand-dependent. Heterodimerizes with B2M, this interaction is required for surface expression. Associated with the peptide-loading complex, TAPBP, CALR and PDIA3. Isoform 3/MR1B homodimerizes and doesn't associates with B2M nor proteins of the peptide-loading complex.

5U1R
STRUCTURE OF HUMAN MR1-DICLOFENAC IN COMPLEX WITH HUMAN MAIT A-F7 TCR
RCSB/PDB
Inspect Structure
See all 3D Structures for MR1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: MR1 is active in the following subcellular-locations: cell membrane, endoplasmic reticulum, endoplasmic reticulum membrane, secreted.
GO terms: MR1 is active in the following subcellular-locations: endoplasmic reticulum, endoplasmic reticulum membrane, external side of plasma membrane, extracellular space, integral component of membrane, MHC class I protein complex, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project MR1 has gain in 0 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: SF_539, MCF7, SR

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MOLP-8, NCI-H196, NCI-H596

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, BJ, SK-N-SH

(see details)

3D Structures


For MR1 there are:
31 structures (60 chains) solved
31 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

MR1 is solved in complex with the approved drug(s):

DIF/DICLOFENAC (5U1R_A, 5U1R_C).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


MR1 has been screened with compounds ( bioactivities). (see details)