Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SERK1 (Q94AG2) - Overview - Molecular Target Synopsis

Protein


SERK1, Somatic embryogenesis receptor kinase 1
Enzyme Classification 2.7.10.1
UniProt Q94AG2

Also Known as SERK1_ARATH, SERK1

Dual specificity kinase acting on both serine/threonine- and tyrosine-containing substrates. Phosphorylates BRI1 on 'Ser-887' and CDC48 on at least one threonine residue and on 'Ser-41'. Confers embryogenic competence. Acts redundantly with SERK2 as a control point for sporophytic development controlling male gametophyte production. Involved in the brassinolide signaling pathway. Monomer, homo- and heterodimer. Interacts with KAPP, CDC48A, GRF6 or GRF7, SERK2, BRI1 and SERK3/BAK1 to form the SERK1 signaling complex. Interacts with the EF-Tu receptor EFR and FLS2 in a specific ligand-induced manner. Interacts with ERECTA in a EPF2-induced manner. Interacts with ERL1 in a EPF1-induced manner. Interacts with TMM (PubMed:26320950).

6FG8
CRYSTAL STRUCTURE OF THE BIR3 - SERK1 COMPLEX FROM ARABIDOPSIS THALIANA.
RCSB/PDB
Inspect Structure
See all 3D Structures for SERK1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
625Q94AG2-1

Sub-cellular localization


UniProt: SERK1 is active in the following subcellular-locations: cell membrane, endoplasmic reticulum membrane.
GO terms: SERK1 is active in the following subcellular-locations: endoplasmic reticulum membrane, integral component of membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SERK1 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

3D Structures


For SERK1 there are:
5 structures (6 chains) solved
5 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SERK1 has been screened with compounds ( bioactivities). (see details)