Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

EMG1 (Q92979) - Overview - Molecular Target Synopsis

Protein


EMG1, Ribosomal RNA small subunit methyltransferase NEP1
Enzyme Classification 2.1.1.-
UniProt Q92979

Also Known as NEP1_HUMAN, EMG1, C2F

S-adenosyl-L-methionine-dependent pseudouridine N(1)-methyltransferase that methylates pseudouridine at position 1248 (Psi1248) in 18S rRNA. Involved the biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA. Is not able to methylate uridine at this position (PubMed:20047967). Has also an essential role in 40S ribosomal subunit biogenesis independent on its methyltransferase activity, facilitating the incorporation of ribosomal protein S19 during the formation of pre-ribosomes (By similarity). Homodimer.

5FAI
EMG1 N1-SPECIFIC PSEUDOURIDINE METHYLTRANSFERASE
RCSB/PDB
Inspect Structure
See all 3D Structures for EMG1

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
244Q92979-1
243ENSG00000126749ENST00000261406ENSP00000476966

Sub-cellular localization


UniProt: EMG1 is active in the following subcellular-locations: nucleolus, nucleus.
GO terms: EMG1 is active in the following subcellular-locations: cytoplasm, nucleolus, nucleoplasm, nucleus, small-subunit processome.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project EMG1 has gain in 4 cell-lines, loss in 1 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HOP_62, NCI_H322M, ACHN

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: MDA-MB-436, LS1034, NCI-H322T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HeLa-S3, A549

(see details)

3D Structures


For EMG1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis