Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RIT1 (Q92963) - Overview - Molecular Target Synopsis

Protein


RIT1, GTP-binding protein Rit1
UniProt Q92963

Also Known as RIT1_HUMAN, RIT1, RIBB, RIT, ROC1

Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation. Interacts with AFDN, the C-terminal domain of RALGDS and RLF, but not with RIN1 and PIK3CA. RLF binds exclusively to the active GTP-bound form. Strongly interacts with BRAF, but only weakly with RAF1. BARF and RAF1 association is dependent upon the GTP-bound state. Interacts with RGL3.

4KLZ
INHIBITION OF SMALL GTPASES BY STABILIZATION OF THE GDP COMPLEX, A NOVEL APPROACH APPLIED TO RIT1, A TARGET FOR RHEUMATOID ARTHRITIS
RCSB/PDB
Inspect Structure
See all 3D Structures for RIT1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RIT1 is active in the following subcellular-locations: cell membrane.
GO terms: RIT1 is active in the following subcellular-locations: plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RIT1 has gain in 6 cell-lines, loss in 0 cell-lines and no signal in 999 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RXF_393, NCI_H322M, A498

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: G112, NCI-H345, G122

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

3D Structures


For RIT1 there are:
1 structures (1 chains) solved
1 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RIT1 has been screened with compounds ( bioactivities). (see details)