Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

SLCO2A1 (Q92959) - Overview - Molecular Target Synopsis

Protein


SLCO2A1, Solute carrier organic anion transporter family member 2A1
UniProt Q92959

Also Known as SO2A1_HUMAN, SLCO2A1, OATP2A1, SLC21A2

May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.

3MRR
10 RESIDUE FRAGMENT OF
10-MERIC PEPTIDE FROM SOLUTE CARRIER ORGANIC ANIONTRANSPORTER FAMILY MEMBER 2A1
IN THE STRUCTURE OF
CRYSTAL STRUCTURE OF MHC CLASS I HLA-A2 MOLECULE COMPLEXED WITH HUMAN PROSTAGLANDIN TRANSPORTER DECAPEPTIDE
RCSB/PDB
Inspect Structure
See all 3D Structures for SLCO2A1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: SLCO2A1 is active in the following subcellular-locations: cell membrane.
GO terms: SLCO2A1 is active in the following subcellular-locations: integral component of plasma membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project SLCO2A1 has gain in 1 cell-lines, loss in 0 cell-lines and no signal in 1004 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: RXF_393, UO_31, SNB_75

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: HCC4006, CAL-12T, NCI-H2452

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, HUVEC, NHLF

(see details)

3D Structures


For SLCO2A1 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


SLCO2A1 has been screened with 47 compounds (54 bioactivities), 12 compounds have bioactivities that show binding affinity of <= 500nM (12 bioactivities). (see details)