RAB8B (Q92930) - Overview - Molecular Target Synopsis
RAB8B, Ras-related protein Rab-8B
Also Known as RAB8B_HUMAN, RAB8B
The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells. Associated with actin, delta-catenin and alpha and beta tubulins (By similarity). Interacts with OTOF (By similarity). Interacts with PEX5R (By similarity). Interacts with RAB3IP. Interacts with VIM (By similarity). Interacts with CDH1 (By similarity). Interacts with MICALL2.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: RAB8B is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle, phagosome, phagosome membrane.
GO terms: RAB8B is active in the following subcellular-locations: cell tip, endosome, extracellular exosome, intracellular membrane-bounded organelle, nuclear body, nucleoplasm, perinuclear region of cytoplasm, peroxisomal membrane, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, recycling endosome membrane, synaptic vesicle, trans-Golgi network transport vesicle.