Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB8B (Q92930) - Overview - Molecular Target Synopsis

Protein


RAB8B, Ras-related protein Rab-8B
UniProt Q92930

Also Known as RAB8B_HUMAN, RAB8B

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may be involved in polarized vesicular trafficking and neurotransmitter release. May participate in cell junction dynamics in Sertoli cells. Associated with actin, delta-catenin and alpha and beta tubulins (By similarity). Interacts with OTOF (By similarity). Interacts with PEX5R (By similarity). Interacts with RAB3IP. Interacts with VIM (By similarity). Interacts with CDH1 (By similarity). Interacts with MICALL2.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RAB8B is active in the following subcellular-locations: cell membrane, cytoplasmic vesicle, phagosome, phagosome membrane.
GO terms: RAB8B is active in the following subcellular-locations: cell tip, endosome, extracellular exosome, intracellular membrane-bounded organelle, nuclear body, nucleoplasm, perinuclear region of cytoplasm, peroxisomal membrane, phagocytic vesicle, phagocytic vesicle membrane, plasma membrane, recycling endosome membrane, synaptic vesicle, trans-Golgi network transport vesicle.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB8B has gain in 1 cell-lines, loss in 2 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: LOXIMVI, NCI_H226, MDA_MB_435

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: COV434, NCI-H2452, COLO-818

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: NHLF, HSMM, AG445

(see details)

3D Structures


At greater than 75% identity similarity to RAB8B there are:
11 structures (28 chains) solved
9 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB8B has been screened with compounds ( bioactivities). (see details)