Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RAB1C (Q92928) - Overview - Molecular Target Synopsis

Protein


RAB1C, Putative Ras-related protein Rab-1C
UniProt Q92928

Also Known as RAB1C_HUMAN, RAB1C

Protein transport. Probably involved in vesicular traffic.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
201Q92928-1

Sub-cellular localization


UniProt: RAB1C is active in the following subcellular-locations: cytoplasm, membrane.
GO terms: RAB1C is active in the following subcellular-locations: Golgi membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RAB1C has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: Hs 746T, NCI-H209, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


At greater than 90% identity similarity to RAB1C there are:
17 structures (40 chains) solved
14 are solved in complex with at least one small molecule ligand
1 are solved with an approved drug

RAB1C is solved in complex with the approved drug(s):

AMP/ADENOSINE PHOSPHATE (3NKV_A, 3NKV_B).

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RAB1C has been screened with compounds ( bioactivities). (see details)