Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

ABCC2 (Q92887) - Overview - Molecular Target Synopsis

Protein


ABCC2, Canalicular multispecific organic anion transporter 1
UniProt Q92887

Also Known as MRP2_HUMAN, ABCC2, CMOAT, CMOAT1, CMRP, MRP2

Mediates hepatobiliary excretion of numerous organic anions. May function as a cellular cisplatin transporter.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
1545ENSG00000023839ENST00000370449ENSP00000359478Q92887-1
293ENSG00000023839ENST00000370434ENSP00000359463

Sub-cellular localization


UniProt: ABCC2 is active in the following subcellular-locations: apical cell membrane.
GO terms: ABCC2 is active in the following subcellular-locations: apical plasma membrane, cell surface, integral component of plasma membrane, membrane, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project ABCC2 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 1005 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A549, NCI_H460, SK_MEL_5

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: huH-1, C3A, NCI-H2122

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, HeLa-S3, HepG2

(see details)

3D Structures


At greater than 50% identity similarity to ABCC2 there are:
6 structures (7 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


ABCC2 has been screened with 869 compounds (1180 bioactivities), 3 compounds have bioactivities that show binding affinity of <= 500nM (4 bioactivities). (see details)