Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

HOXB13 (Q92826) - Overview - Molecular Target Synopsis

Protein


HOXB13, Homeobox protein Hox-B13
UniProt Q92826

Also Known as HXB13_HUMAN, HOXB13

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds preferentially to methylated DNA (PubMed:28473536). Heterodimer with MEIS1 (PubMed:28473536). Heterodimer with MEIS2 (Ref.8).

5NO6
TEAD4-HOXB13 COMPLEX BOUND TO DNA
RCSB/PDB
Inspect Structure
See all 3D Structures for HOXB13

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
284ENSG00000159184ENST00000290295ENSP00000290295Q92826-1

Sub-cellular localization


UniProt: HOXB13 is active in the following subcellular-locations: nucleus.
GO terms: HOXB13 is active in the following subcellular-locations: nucleoplasm, transcription factor complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project HOXB13 has gain in 8 cell-lines, loss in 0 cell-lines and no signal in 997 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: PC_3, UACC_257, COLO205

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: LNCAP, PC-3, SK-MEL-3

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For HOXB13 there are:
7 structures (17 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


HOXB13 has been screened with compounds ( bioactivities). (see details)