Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

PCSK5 (Q92824) - Overview - Molecular Target Synopsis

Protein


PCSK5, Proprotein convertase subtilisin/kexin type 5
Enzyme Classification 3.4.21.-
UniProt Q92824

Also Known as PCSK5_HUMAN, PCSK5, PC5, PC6

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: PCSK5 is active in the following subcellular-locations: endomembrane system, secreted.
GO terms: PCSK5 is active in the following subcellular-locations: extracellular region, extracellular space, Golgi apparatus, Golgi lumen, integral component of Golgi membrane, membrane, secretory granule, trans-Golgi network.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project PCSK5 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: A498, 786_0, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVISE, ME-180, MKN-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)

3D Structures


At greater than 50% identity similarity to PCSK5 there are:
21 structures (44 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


PCSK5 has been screened with 11 compounds (11 bioactivities), 9 compounds have bioactivities that show binding affinity of <= 500nM (9 bioactivities). (see details)