PCSK5 (Q92824) - Overview - Molecular Target Synopsis
PCSK5, Proprotein convertase subtilisin/kexin type 5
Enzyme Classification 3.4.21.-
Also Known as PCSK5_HUMAN, PCSK5, PC5, PC6
Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
UniProt: PCSK5 is active in the following subcellular-locations: endomembrane system, secreted.
GO terms: PCSK5 is active in the following subcellular-locations: extracellular region, extracellular space, Golgi apparatus, Golgi lumen, integral component of Golgi membrane, membrane, secretory granule, trans-Golgi network.