Molecular Target Synopsis
Domains and Structures
Drugs and Clinical Candidates
Ligand Efficiency Plot
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
Germline Genetics

PCSK5 (Q92824) - Overview - Molecular Target Synopsis


PCSK5, Proprotein convertase subtilisin/kexin type 5
Enzyme Classification 3.4.21.-
UniProt Q92824

Also Known as PCSK5_HUMAN, PCSK5, PC5, PC6

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive and regulated secretory pathways. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.

Isoforms / Transcripts (Protein Coding)

Sub-cellular localization

UniProt: PCSK5 is active in the following subcellular-locations: endomembrane system, secreted.
GO terms: PCSK5 is active in the following subcellular-locations: extracellular region, extracellular space, Golgi apparatus, Golgi lumen, integral component of Golgi membrane, membrane, secretory granule, trans-Golgi network.

GO terms

Gene Copy Number Variation

In COSMIC - Cell Lines Project PCSK5 has gain in 2 cell-lines, loss in 3 cell-lines and no signal in 1000 cell-lines. (see details)

Gene Expression

In NCI60, the highest expressing cell lines are: A498, 786_0, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: OVISE, ME-180, MKN-1

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HMEC

(see details)

3D Structures

At greater than 50% identity similarity to PCSK5 there are:
21 structures (44 chains) solved
3 are solved in complex with at least one small molecule ligand

(see details)
Molecular Target 3D Synopsis

Screening and Chemistry

PCSK5 has been screened with 11 compounds (11 bioactivities), 9 compounds have bioactivities that show binding affinity of <= 500nM (9 bioactivities). (see details)