Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

TAF15 (Q92804) - Overview - Molecular Target Synopsis

Protein


TAF15, TATA-binding protein-associated factor 2N
UniProt Q92804

Also Known as RBP56_HUMAN, TAF15, RBP56, TAF2N

RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II). Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1.

2MMY
SOLUTION STRUCTURE OF THE RNA RECOGNITION MOTIF OF HUMAN TAF15
RCSB/PDB
Inspect Structure
See all 3D Structures for TAF15

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
592ENSG00000172660ENST00000588240ENSP00000466950Q92804-1
589ENSG00000172660ENST00000311979ENSP00000309558Q92804-2

Sub-cellular localization


UniProt: TAF15 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: TAF15 is active in the following subcellular-locations: cytoplasm, nucleoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project TAF15 has gain in 0 cell-lines, loss in 0 cell-lines and no signal in 0 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: HT29, NCI_H522, CCRF_CEM

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: WiDr, G122, HT-29

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, IMR-90

(see details)

3D Structures


For TAF15 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


TAF15 has been screened with compounds ( bioactivities). (see details)