Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

P3H4 (Q92791) - Overview - Molecular Target Synopsis

Protein


P3H4, Endoplasmic reticulum protein SC65
UniProt Q92791

Also Known as SC65_HUMAN, P3H4, LEPREL4, NOL55, SC65

Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Interacts with PLOD1, P3H3 and PPIB. Identified in a complex with PLOD1 and P3H3.

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: P3H4 is active in the following subcellular-locations: endoplasmic reticulum.
GO terms: P3H4 is active in the following subcellular-locations: catalytic complex, condensed nuclear chromosome, endoplasmic reticulum, nucleolus, synaptonemal complex.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project P3H4 has gain in 4 cell-lines, loss in 3 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are:

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H1581, SCC-9, Hs 695T

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, A549, IMR-90

(see details)