P3H4 (Q92791) - Overview - Molecular Target Synopsis
P3H4, Endoplasmic reticulum protein SC65
Also Known as SC65_HUMAN, P3H4, LEPREL4, NOL55, SC65
Part of a complex composed of PLOD1, P3H3 and P3H4 that catalyzes hydroxylation of lysine residues in collagen alpha chains and is required for normal assembly and cross-linking of collagen fibrils. Required for normal bone density and normal skin stability via its role in hydroxylation of lysine residues in collagen alpha chains and in collagen fibril assembly. Interacts with PLOD1, P3H3 and PPIB. Identified in a complex with PLOD1 and P3H3.
|Protein Length||Ensembl Gene||Ensembl Transcript||Ensembl Protein||Uniprot Isoform|
|437||ENSG00000141696||ENST00000355468, ENST00000393928||ENSP00000347649, ENSP00000377505||Q92791-1|
UniProt: P3H4 is active in the following subcellular-locations: endoplasmic reticulum.
GO terms: P3H4 is active in the following subcellular-locations: catalytic complex, condensed nuclear chromosome, endoplasmic reticulum, nucleolus, synaptonemal complex.