Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

CDKL2 (Q92772) - Overview - Molecular Target Synopsis

Protein


CDKL2, Cyclin-dependent kinase-like 2
Enzyme Classification 2.7.11.22
UniProt Q92772

Also Known as CDKL2_HUMAN, CDKL2


4BBM
CRYSTAL STRUCTURE OF THE HUMAN CDKL2 KINASE DOMAIN WITH BOUND TCS 2312
RCSB/PDB
Inspect Structure
See all 3D Structures for CDKL2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: CDKL2 is active in the following subcellular-locations: cytoplasm, nucleus.
GO terms: CDKL2 is active in the following subcellular-locations: centrosome, cytoplasm, nucleus.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project CDKL2 has gain in 1 cell-lines, loss in 1 cell-lines and no signal in 1003 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SK_OV_3, NCI_H460

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: TC-71, NCI-H1395, LN-18

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

RNA Interference


CDKL2 was reported in the following RNAI studies:

Cell - Large Scale Profiling of Kinase Dependencies in Cancer Cell Lines, the highest RNAi cell lines are: A427, COV504. (see details)

3D Structures


For CDKL2 there are:
2 structures (3 chains) solved
2 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


CDKL2 has been screened with 89 compounds (95 bioactivities), 7 compounds have bioactivities that show binding affinity of <= 500nM (9 bioactivities). (see details)