Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RYR2 (Q92736) - Overview - Molecular Target Synopsis

Protein


RYR2, Ryanodine receptor 2
UniProt Q92736

Also Known as RYR2_HUMAN, RYR2

Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development. Homotetramer. Can also form heterotetramers with RYR1 and RYR3 (By similarity). Interacts with FKBP1A and FKBP1B; these interactions may stabilize the channel in its closed state and prevent Ca(2+) leaks. Interacts with CALM and S100A1; these interactions regulate channel activity. Identified in a complex composed of RYR2, FKBP1B, PKA catalytic subunit, PRKAR2A, AKAP6, and the protein phosphatases PP2A and PP1. Interacts directly with FKBP1B, PKA, PP1 and PP2A. Interacts with SELENON (By similarity). In cardiac muscles, identified in a complex, composed of FSD2, CMYA5 and RYR2.

4JKQ
CRYSTAL STRUCTURE OF THE N-TERMINAL REGION OF THE HUMAN RYANODINE RECEPTOR 2
RCSB/PDB
Inspect Structure
See all 3D Structures for RYR2

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RYR2 is active in the following subcellular-locations: membrane, sarcoplasmic reticulum, sarcoplasmic reticulum membrane.
GO terms: RYR2 is active in the following subcellular-locations: calcium channel complex, cytoplasmic vesicle membrane, junctional sarcoplasmic reticulum membrane, membrane, plasma membrane, protein-containing complex, sarcolemma, sarcoplasmic reticulum, sarcoplasmic reticulum membrane, smooth endoplasmic reticulum, Z disc.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RYR2 has gain in 3 cell-lines, loss in 1 cell-lines and no signal in 1001 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, SR, SK_OV_3

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SR, IM-95m, SCLC-22H

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)

3D Structures


For RYR2 there are:
1 structures (1 chains) solved
0 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RYR2 has been screened with compounds ( bioactivities). (see details)