Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RND1 (Q92730) - Overview - Molecular Target Synopsis

Protein


RND1, Rho-related GTP-binding protein Rho6
UniProt Q92730

Also Known as RND1_HUMAN, RND1, RHO6

Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments. Binds GRB7 and PLXNB1. Interacts with UBXD5. Interacts with PLXNA2.

3Q3J
CRYSTAL STRUCTURE OF PLEXIN A2 RBD IN COMPLEX WITH RND1
RCSB/PDB
Inspect Structure
See all 3D Structures for RND1

Isoforms / Transcripts (Protein Coding)


Sub-cellular localization


UniProt: RND1 is active in the following subcellular-locations: cell membrane, cytoplasm, cytoskeleton.
GO terms: RND1 is active in the following subcellular-locations: actin cytoskeleton, adherens junction, cell cortex, cell division site, cytoplasm, cytosol, intracellular membrane-bounded organelle, plasma membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RND1 has gain in 3 cell-lines, loss in 0 cell-lines and no signal in 1002 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: MCF7, A549, T47D

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: NCI-H2110, NCI-H820, NCI-H1781

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: A549, SK-N-SH, NHLF

(see details)

3D Structures


For RND1 there are:
3 structures (5 chains) solved
3 are solved in complex with at least one small molecule ligand



(see details)
Molecular Target 3D Synopsis

Screening and Chemistry


RND1 has been screened with compounds ( bioactivities). (see details)