Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

MAML1 (Q92585) - Druggability - Molecular Target Synopsis

Chain-based assessment (last updated 08/10/2019)
Domain-based assessment (last updated 30/07/2012)


Structural Druggability Help: Help

Chain-based assessment (last updated 08/10/2019)


Chains assessed5
Chains with at least one site assessed as druggable using the strict criteria1
Chains with at least one site assessed as druggable using the relaxed criteria1


		
PDB Chain Protein Name Druggable Relaxed Druggable Strict Details
3NBN_F Mastermind-like protein 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.38 51.2 13.1 No No
2 empty 2.54 61.4 13.9 No No
3 empty 2.38 53.9 13.1 No No
4 empty 2.3 58.1 9.3 No No
5 empty 2.74 67.6 8.3 No No
6 empty 2.23 57.7 11.3 No No
7 empty 2.19 57.5 11.9 No No
8 empty 2.56 54.3 10.1 No No
9 empty 1.71 63.4 6.2 No No
10 empty 2.64 67.6 6.8 No No
6SMV_A Mastermind-like protein 1 Yes Yes show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 bound 1.74 71.8 67.8 Yes Yes
2 empty 1.81 65.8 28.2 No No
3 empty 2.33 63.9 31.3 No No
4 empty 2.06 66.6 24.4 No No
5 empty 2.36 74.2 20 No No
6 empty 2.2 65.4 21 No No
7 empty 1.96 72.8 11.5 No No
8 empty 2.06 61 17.1 No No
9 empty 2.14 63 13.9 No No
10 empty 2.25 65.1 10.4 No No
3NBN_C Mastermind-like protein 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.22 60 19 No No
2 empty 2.41 50.8 14.1 No No
3 empty 2.38 55.9 12.6 No No
4 empty 2.28 55.6 7.6 No No
5 empty 2.35 57.8 11.5 No No
6 empty 2.21 57.1 10.4 No No
7 empty 2.62 65.4 10.4 No No
8 empty 2.67 56.1 9.5 No No
9 empty 3.29 75 5.5 No No
10 empty 2.78 72.9 5.5 No No
2F8X_M Mastermind-like protein 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 58.5 13.9 No No
2 empty 2.29 54.1 13.7 No No
3 empty 2.8 64.9 13.6 No No
4 empty 2.47 49.4 12 No No
5 empty 2.65 65.9 8.8 No No
6 empty 2.25 55.4 9 No No
7 empty 2.16 51.5 11.3 No No
8 empty 2.7 62.6 6.2 No No
9 empty 2.34 45.8 7.9 No No
10 empty 2.98 66.1 5.8 No No
3V79_M Mastermind-like protein 1 No No show/hide
Site num Site Status Pickpocket Polar Ratio Surfnet Gap Vertices Buried Surfnet Long Axis Druggable Relaxed Druggable Strict
1 empty 2.32 57.4 13.4 No No
2 empty 2.36 48.4 11.2 No No
3 empty 2.62 65.9 10 No No
4 empty 2.28 56 10.4 No No
5 empty 2.54 56.8 7.2 No No
6 empty 2.1 56.5 9.4 No No
7 empty 2.59 39.2 8.4 No No
8 empty 2.21 52.5 12.3 No No
9 empty 1.92 56.8 8.5 No No
10 empty 2.78 66.7 6.5 No No

Domain-based assessment (last updated 30/07/2012)


Domains assessed2
Domains assessed as druggable using the strict criteria0
Domains assessed as druggable using the relaxed criteria0

PDB (Domain) Protein Name Domain Resolution Ligands Druggable Relaxed Druggable Strict
2F8X_M (3090010) Mastermind-like protein 1 PFAM, PFAM, PFAM MamL-1 3.25Å No No
3NBN_C (3630847) Mastermind-like protein 1 PFAM, PFAM, PFAM MamL-1 3.45Å No No
Ligand-based Druggability Score: -3
Ligand-based Druggability Score Percentile: 59%
Ligand-based Druggability Help: Help




		
Number of proteins in the network : 13346


MAML1 is involved in 10 interactions in the network.


Druggability
Overall Druggability Percentile: 32.48
Druggability for Cancer Therapeutics: 81.87
Druggability for Other Therapeutics: 51.56
Cancer-Associated
Cancer-associated percentile : 94.30
Network Articulation Point
Is MAML1 critical for communication in the network?


Detailed Graph Legend:Help