Molecular Target Synopsis
Overview
Domains and Structures
Drugs and Clinical Candidates
Druggability
Chemistry
Ligand Efficiency Plot
Pathways
Family Cladogram
Interaction Network
Gene Expression
Gene Copy Number Variation
RNAi
Mutations
Germline Genetics

RGP1 (Q92546) - Overview - Molecular Target Synopsis

Protein


RGP1, RAB6A-GEF complex partner protein 2
UniProt Q92546

Also Known as RGP1_HUMAN, RGP1, KIAA0258

The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Forms a complex with RIC1; the interaction enhances RAB6A GTPase activity. Interacts with RIC1. Interacts with RAB6A; the interaction is direct with a preference for RAB6A-GDP. Interacts with RAB33B.

Isoforms / Transcripts (Protein Coding)


Protein Length Ensembl Gene Ensembl Transcript Ensembl Protein Uniprot Isoform
431ENSG00000107185ENST00000456972ENSP00000409466
391ENSG00000107185ENST00000378078ENSP00000367318Q92546-1

Sub-cellular localization


UniProt: RGP1 is active in the following subcellular-locations: cytoplasm, cytosol, membrane.
GO terms: RGP1 is active in the following subcellular-locations: cytosol, Golgi membrane, membrane, plasma membrane, protein-containing complex, RIC1-RGP1 guanyl-nucleotide exchange factor complex, trans-Golgi network membrane.



UniProt
GO terms

Gene Copy Number Variation


In COSMIC - Cell Lines Project RGP1 has gain in 4 cell-lines, loss in 3 cell-lines and no signal in 998 cell-lines. (see details)

Gene Expression


In NCI60, the highest expressing cell lines are: DU_145, SNB_75, U251

In Array Express (RNA-seq of 675 commonly used human cancer cell lines), the highest expressing cell lines are: SCC-9, DOK, MKN-74

In Array Express (RNA-seq of long poly adenylated RNA and long non poly adenylated RNA from ENCODE cell lines), the highest expressing cell lines are: SK-N-SH, NHLF, HSMM

(see details)